Bio
Dr. Umar Saeed is a distinguished researcher affiliated with the National University of Sciences and Technology (NUST) in Islamabad, Pakistan. He holds an MS/M-Phil in Applied Biosciences (Healthcare Biotechnology) and has made significant contributions to the fields of molecular biology, epidemiology, and public health. His authored works include studies on cyclin-dependent kinases in cell cycle regulation, the impact of consanguineous marriages on thalassemia prevalence, and risk factors for hepatitis B and C transmission in Pakistan. Dr. Saeed has published over 155 works, amassing more than 30,000 citations, with an h-index of 48 and an i10-index of 82. He also serves as a reviewer for the Global Journal of Medical Research (GJMR), reflecting his active engagement in scientific peer review.
Educational Journey
MS/ M-Phil • Applied Biosciences: Major Healthcare Biotechnology
Experience
Nokia Oyj
0 - PresentAtta-ur-Rahman School of Applied Biosciences
0 - 0Editors Role
Reviewer
GJMR
2013 -Research
Risk Factors Associated with Transmission of Hepatitis B and Hepatitis C Virus in Pakistan
In Pakistan about 7 to 9 million people are living with HBV and 10 million people are living with HCV, with higher morbidity and mortality. This article reviews prevalence of Hepatitis B and Hepatitis C virus in Pakistan and risk factors associated with transmission of viral hepatitis. A literature search was conducted on research articles from Pubmed, PakMediNet and Google scholar. Prevalence of HBV and HCV infection varies in different regions due to inadequate knowledge and non implementation of international health standards. Majority of Pakistani population lives in rural areas as compared to urban areas. But unfortunately, up to date, no prevalence study has been reported from rural areas of Pakistan depicting HBV and HCV infection. Prevalence of HBV in general population, peds, pregnant women and IDUs was reported 4.5%, 1.8%, 0.34% to 12.62% and 22.4% respectively. Prevalence of HCV in general adult population, pediatric population, young population applying for recruitment, injecting drug users and multitransfused population was reported 4.95%, 1.72%, 3.64%, 57% and 48.67% respectively. Due to rapidly increasing threat of viral prevalence in Pakistani societies, it is hypothesized that Pakistan neither need enemies nor nuclear war; instead its rapidly increasing hepatitis epidemics can potentially wipeout the entire nation.
Roles of Cyclin Dependent Kinase and CDK-Activating Kinase in Cell cycle Regulation: Contemplation of Intracellular Interactions and Functional Characterization
Cyclin dependent protein kinases (CDKs) play vital role in gene expression and cell cycle regulation. CDKs require cyclin binding activity, phosphorylation through CDK activating kinase (CAK), Cdc25, Wee 1 kinase. Non-cyclin CDK activators include CDK5 activators, Viral Cyclins and RINGO/Speedy. Among all CDK activators, CAK carries prime importance. The time frame of activating phosphorylation varies across different model organisms. A literature search was performed via using Keywords: Cyclin-dependent kinases, CDK activating kinases, Interactions of CDK activating kinase, Association of CDK activating enzymes with cellular proteins, Cell cycle regulation via CDKs, Structure and Function of CDK activating kinases in Pubmed and Google scholar. The key findings on the basis of previous studies illustrated that the CDK3, CDK4 and CDK6 are associated with regulation of G1-S phase transition; CDK2 is involved in entrance to S phase and DNA replication; while CDK1 is vital for mitosis. The CDK activity is regulated via cyclin binding, cyclin-dependent kinase inhibitors CKIs, CDK phosphorylation at ATP-binding pocket for inhibition while for activation CDK phosphorylation occurs at T-loop conserved residue. Structural and functional characterization of CDK activating kinases and interactions with other cellular proteins were also discussed in detail. Loss of CAK activity usually leads toward transcriptional defects and cell cycle arrest. Identification of CDK and CDK activating kinases inhibitors could provide potential therapeutic options against human neoplasias.
