Dr. Venkatesan Natarajan

Formulation of an Antidiabetic Herbal Capsule from Isolated Compounds of Ethanolic Extract of Dregea Volubilis and Leptadenia Reticulata

The present investigation was aimed to formulate capsule formulations containing isolated compounds from Dregea volubilis and Leptadenia reticulata. In order to obtain anti diabetic formulations with more effective oral hypoglycemic activity, less side effects, increased patient compliance thereby providing multifaceted benefits. DVLR (DV and LR isolated fraction was mixed in 1:1 ratio) capsules were formulated and the study was carried out for its antidiabetic effect of STZ and HFD induced diabetic rats. Preformulation of capsules were observed as angle of repose and bulk density. Finished capsule formulations were evaluated for weight variation, pH, moisture content, disintegration time, in vitro-drug release percentage and in vivo anti diabetic studies. In our study showed empty capsule shell pH was observed as 3.62 and moisture content of capsule was found as <5 % w/w which indicated that there were less chances of microbial growth and capsule will not become soft. Filled capsule passed the test for uniformity of weight, all capsules disintegrated within 7 minutes.