Dr. Vickram
Chronic Kidney Disease and Diabetes Diet, Metabolism, and Disease Garlic and Onion Studies Liver Disease Diagnosis and Treatment Analytical Chemistry and Chromatography IoT-based Control Systems Gout, Hyperuricemia, Uric Acid Sulfur Compounds in Biology Advanced Glycation End Products research Endocrinology, Diabetes and Metabolism Nephrology Plant Science Epidemiology Spectroscopy Computer Science Applications Biochemistry Clinical Biochemistry

Bio

Dr. R. T. Kashinath is a Professor in the Department of Biochemistry at Subbaiah Institute of Medical Sciences in Shimoga, Karnataka, India. He holds an M.Sc. and Ph.D. in Biochemistry (Medical Faculty) and is a Fellow of the Indian College of Surgeons (FICS).

Experience

Subbaiah Institute of Medical Sciences

Professor

0 - 0 • Biochemistry

Basaveshwara Medical College & Hospital

0 - 0

Vijayanagara Institute of Medical Sciences

0 - 0
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Editors Role

Reviewer

Global Journal of Medical Research (GJMR)

2012 -

Affiliations

Indian College of Surgeons

Fellow

Member since 0

Research

THIOPROPANOL INDUCED CHANGES IN GLYCOGEN BREAKDOWN IN ALLOXAN DIABETIC LIVER

Article January 1, 1970

Liver glycogen content and liver glycogen synthesis are lowered in diabetes mellitus due to lack of functioning insulin. Many enzymes of glycogen metabolism as well as glucose metabolism are sulfhydryl in nature and are affected by changes in cellular thiol-disulfide ratio. Certain low molecular weight thiols can influence glucose uptake and utilization in fat cells and in muscle cells. A study was undertaken to establish the effect of thiopropanol ( 3-mercapto 1 propanol) on glycogen breakdown in isolated alloxan diabetic liver. The results indicate that thiopropanol influences glycogen breakdown, lactic acid production in alloxan diabetic liver which may be attributed to increased activity of hexokinase in thiopropanol-exposed-alloxan diabetic liver

Effect of Thiopropanol on Glucose Utilization in Alloxan Diabetic Rat Liver

Article January 1, 1970

Cellular thiol-disulfide ratio can be altered by exogenously added, readily absorbable thiols or disulfides. Many sulphydryl enzymes including glycolytic kinases are known to be affected by changes in thiol-disulfide balance. It is known that in diabetes mellitus the tissue total thiol concentration is reduced thereby creating disturbances in various metabolic pathways, especially the pathways of carbohydrate metabolism. Few studies have suggested that the alterations in carbohydrate metabolism can be directly attributed to modifications in tissue thioldisulfide balance. Certain low molecular weight thiols are known to influence glucose utilization in adipocytes probably by replenishing cellular NADP levels hence favoring utility of glucose through HMP pathway. A study was undertaken to assess the effect of Thiopropanol(3- mercapto-1- propanol), a low molecular weight thiol, on glucose utilization in isolated alloxan diabetic liver slices. The results indicate that the thiopropanol at the dosage employed in the present study influences glucose utilization, lactate production, pyruvate production, glucose-6- phosphate dehydrogenase as well as hexokinase activities in isolated alloxan diabetic liver slices, probably by favoring glucose utilization through glycolysis as well as through HMP pathway.