This study provides panel data evidence on the determinants of foreign direct investment (FDI) for a sample of 45 African countries over the period 1980 to 2009. Using dynamic panel data estimation techniques, the study identifies a number of factors that affect FDI flows in Africa, including, agglomeration economies, natural resources, real GDP growth, and international investmentgreements. The study also shows that the Africa-wide environment has become more conducive to FDI since the year 2000.