The histostructure of fish liver from Sitnica river was studied in order to detect the effects of pollution of Sitnica River in Kosovo.Fish (n=21) were sampled during March-May and August-September of 2010-2012 from sites Ferizaj, Vragoli and Plemetin (Sitnica River). The morphological alterations in the liver were mainly more degenerative in fish from Vragoli and Plementin polluted sites than Ferizaj one. Ferizaj is source of the river site, so it is less contaminated than the two other sites. Fish liver histopathology is a good bioindicator and can be used for detection of chemical pollution in fish. Based on results of our research we can conclude that “Sitnica” River is polluted river mainly by industrial and urban discharge of liquid waste products.