An experiment was carried out on Cob 500 broiler chickens at Swine and Avian Research Program, Khumaltar, Lalitpur to evaluate the growth performance of broiler chicken fed with normal Vs QPM based diet and with supplementation of synthetic lysine and methionine in both maize for 54 days (16 days starter and 38 days for finisher). The experimental day old birds were procured from Valley Feed, Bajalu, Kathmandu and were allotted into four treatments with three replications having 15 birds in each replication by using Complete Randomized Design (CRD). All experimental birds were vaccinated with F1 vaccine @ one drop / bird against Ranikhet at the first week and vaccinated with IB+ND vaccine against Gumbaro at 2nd and 5th weeks of experiment. Birds of T1 were provided normal maize based diet, T2 normal maize based diet with supplementation of synthetic lysine and methionine, T3 QPM based diet and T4 QPM based diet with supplementation of synthetic lysine and methionine. Concentrate mixture feeding was done on group basis and was provided to the experimental birds of all groups once a day (morning) in adlib amount for both periods (starter – 16 days and finisher – 38 days) of the experiment. Quantity of concentrate mixture given daily to the birds in groups weighed daily and refusal was weighed in the next morning. Experiment revealed that cumulative feed intake was found to be higher in QPM based diet group (5597 g) followed by QPM based diet with supplementation of synthetic lysine and methionine group (5403 g) and normal maize based diet with supplementation with synthetic lysine and methionine group (5377 g). The least feed consumption was recorded for normal maize based diet group (4937 g) which was none significant among diet groups. Similarly, total weight gain was found to be higher for QPM based diet with supplementation of synthetic lysine and methionine group (2180 g) followed by normal maize based diet with supplementation with synthetic lysine and methi