Purpose: To evaluate the Response and Efficacy of weekly paclitaxel with concurrent radiotherapy in comparison to weekly cislatin with concurrent radiotherapy in advanced cervical cancer patients. Methods: Patients coming to the department of radiotherapy S.M.S Hospital were included in the study.50 patients of advanced squamous cell carcinoma of cervix FIGO stage III &IV were selected. In the study and control group , patients were given 5 weeks of external beam radiotherapy followed by brachytherapy. External beam irradiation each of 200cGy/fr, on linear acceleretor by parallel opposed – anterior and posterior fields was given. External beam irradiation was followed by Intracavitary brachytherapy 700cGy/week for 3 weeks each with High Dose Rate Iridium 192 source. Patients received 50 Gy by External beam irradiation (200cGy/fr, total 25 Fr) and 21 Gy by Intracavitary brachytherapy (7Gy/fr, 3fr) .In control group, patients were treated by concurrent weekly cisplatin with external beam radiotherapy.In study group patients were treated by concurrent weekly paclitaxel with external beam radiotherapy.