Background: Distribution character of fats can influence to emergence of different severe life-threatens diseases.Body lipids morphology is enough well investigated, but there is little data on the calorific properties of various lipids, including atherosclerotic plaque (AP).Aim of the study was to investigate the calorific properties of a human body lipids of various anatomical sites. Methods : Trial design is a prospective randomized pilot physical experimental trial. Adipose tissue in the amount of 252 samples from 36 individuals (17 female sex) at autopsy. The subjects were dying from various injuries and were between 36-54 years old. Interventions: Differential scanning calorimetry («Mettler Toledo», USA) was used with an increments temperature of 10.37 °C per minute. In an experimental set up specimens were heated up from 26.0 °C to 700.0 °C for 70.0 minutes. Results: The heat capacity of the studied lipids decreases from AP (dense) to AP (loose), VF (omentum fat), SF (umbilical area), SF (shoulder area), SF (buttock area) and VF (pararenal fat). The dense AP (-3, 97±0,16oC) has higher a heat capacity (p=0.02) than the loose AP (-3, 44±0,15oC). The lowest thermal capacity has a pararenal fat of VF (-1, 25±0,21oC) in compare with SF (buttock area) (p=0.027). ConclusionsIn: Conclusion, the fats of a human body have different calorific properties depending on a location. Atherosclerotic plaques carry the highest energy potential in comparison to the other body lipids. The lowest thermal capacity has pararenal fats. The results of the study suggest that an atherosclerotic plaque is not an accidental phenomenon in the body, but it is a logical pathophysiological process in result of fats compaction.