Seizures are the most noticeable clinical manifestations of epilepsy; measurement of the hippocampus on magnetic resonance (MR) images of the brain has been useful for the assessment of patients with seizures. Therefore this study aimed to diagnose subjects who had developed epilepsy by measuring the RT and LT hippocampus area and volume considering epilepsy duration, seizure frequency, EEG results, T2 signal intensity, treatment, and children ages as well as to correlate the MRI findings with EEG findings. This Study was conducted at Gezira University- MRI Diagnostic center –Khartoum –Sudan during the period from 2010up to2011using Siemens 0.5 Tesla MRI machine. A total of 29 Sudanese children of both genders with clinical history of generalized seizures, and 17 normal children who were selected as control group at different ages were involved in this study. Children with head injury or organic lesion found on MR images were excluded.