Menopause is a major physiological event and is associated with metabolic changes. In order to study the changes associated with bone related parameters present study was planned. The study comprised 100 post menopausal women as study group and 100 ideal weight healthy premenopausal women as control. The blood samples were analyzed for following biochemical parameters serum calcium, phosphorus, alkaline phosphatase and calcitrol. Results revealed that the significant changes observed in calcium, phosphorus and calcitriol when compared to control.