Objective: To assess the role of DWI and the ADC in differentiating between local tumor recurrence and benign breast changes after breast conservative surgery. Materials and Methods: 26 patients (age range, 25–68 years; mean age, 49 years) with breast conservation surgery were included in our study. MRI study was done using bilateral fatsuppressed T2- weighted fast spin-echo, axial STIR, axial T1- weighted fast spin-echo. DWI series were acquired using echo planar imaging pulse sequences incorporating with diffusion gradients and finally dynamic contrast enhancement study was done. Results: Among the twenty sex patients underwent MR imaging in our study, 7 patients were diagnosed at histopathology as local tumor recurrence at the site of surgery, and 11 patients had surgical scarring, 6 patients had seromas, one patient had hematoma and one patient had fat necrosis. Local tumor recurrence showed lower ADC values (mean ADC = 0.95 ± 0.37 x 10-3 mm2/s) than that of benign lesions (mean ADC = 1.69 ± 0.16 x 10-3 mm2/s). The sensitivity and specificity of DWI in the differentiating local tumor recurrence from benign breast lesions were 100 % and 94.7 %, respectively. Conclusion: DWI is easy to obtain in short scan time and easy to evaluate, and ADC values can differentiate between local tumor recurrence and benign breast changes after breast conservation surgery with high sensitivity & specificity.