Drug adulteration is commonly reported in Nigeria. Halofantrine purchased in four different locations in Ondo and Ekiti state, Nigeria were tested in mice for their comparative efficacy. The average parasite clearance time (PCT) were 4.4±0.49, 4.2±0.40, 4.4±0.80 and 4.2±0.75 for Halofantrine coded HAL-AK, HAL-IO, HAL-AD and HAL-IK respectively. Also, average parasite clearance rate (PCR) were 8653±2557, 6895±1010, 5426±1850 and 6226±1850 respectively. The result shows that there was no significant difference in the PCR (P>0.05) between the drugs. All the halofantrine drugscompletely cleared the parasites within 4-5 days. The results of this study indicates that adulteration of Halofantrine is not presently in circulation in areas of Ondo and Ekiti states, South Western Nigeria