Manufacturing is one of the most important contents on the economical plate in Guangzhou. Accelerating the adjustment of manufacturing structure and promoting its optimization and upgrade are the major strategic tasks to create a new version of economic transformation and upgrade in Guangzhou. In this paper, a single structure-DSSA (Dynamic Shift-Share Analysis) model has been proposed which collect the data from 2001 to 2011. Then we use this model to obtain the differences in data of industrial structure and discuss the dynamic change of manufacturing structure in Guangzhou during this period. Then it provide the conversion of direction and strategic selections which would further accelerate the adjustment of manufacturing structure and promote its optimization and upgrade in the future.