Developmental enamel defects of primary dentition result from effect of various systemic problems during pre and early post natal periods. These defects also act as virtual memory of early developmental stresses/events. Primary tooth hypoplasias are risk factors for occurrence of other dental deformities. Multiplicity and severity of the lesions make treatment procedures complex. Establishment of Dental home as early as pregnancy can be done for preventing the deleterious effects of the disease. The author is of opinion that pediatric dentists especially should be aware of this condition because 1) These children are more likely to visit dental service at a younger age because the condition presents early in childhood, 2) Severe morbidity leading to handicapped dentition at early age, 3) complexity of disease as well as its treatment.