The onerous task of protecting orphans in Africa requires a multifarious effort aimed not only at infusion of public, private or international funding into the care and treatment of HIV/AIDS but also the building of economic and legal systems that integrates social and cultural representation and identity of the people such as those that energize the primary base and involve these vulnerable victims of HIV/AIDS. Goals and objectives of governments and institutions working in this field of health should be a collaborative effort towards an effective coordination of work strategically designed for children in partnership with mental health, social, medical and legal personnel. It is my opinion that this will promote easy access to all available resources especially in countries such as Nigeria, Uganda and South Africa where HIV/AIDS is very endemic. In order to prevent abuse and improve access to health care, ethical and legal issues, much attention should be paid to the underlying social and economic problems that contributed to the spread of the disease. Orphans have been greatly affected by the high level of poverty, infectious diseases reaching epidemic levels, lack of education and inadequate health, legal, social and economic infrastructures.