Objective: Analysis were under taken to determine the role of birth asphyxia and chronic antenatal hypoxia disorders in the genesis of Cerebral palsy, in a prospective study of 31,804 antenatal mothers and30,080 live births. Material & Methods: For this large-scale prospective study, proper documentation of all events in the antenatal, natal and postnatal period, a detail, stringent protocol was prepared and distributed to 49 Govt. & Z.P. health institutes. The protocol was filled in for each antenatal mother by the doctor of antenatal clinic and who is attending the delivery. The same was collected back to us by above-mentioned institutes on a fixed date of every month, at the time of monthly review meeting.