Introduction: For renal diseases, renal biopsy is considered gold standard to reach a diagnosis. The present study was undertaken to understand and analyze clinical symptoms, lab findings and final histological diagnosis for clinico-pathological correlation. Material and Methods: The present prospective study comprised of 127 patients who underwent per-cutaneous renal biopsies over a period of three years. Before undertaking renal biopsies the clinical findings along with biochemical and urinary investigations were done.