Background: Jaundice due to biliary obstruction may be caused by a heterogeneous group of diseases that include both benign and malignant conditions. As patients with obstructive jaundice have high morbidity and mortality, early diagnosis of the cause of obstruction is very important especially in malignant cases, as resection is only possible at that stage. Objectives: To determine the etiological spectrum of obstructive jaundice in a tertiary care hospital. Methods: Cross sectional observational study was done in this study. A detailed history and thorough physical examination followed by investigations including liver function test, ultrasonography of whole abdomen & in some selective cases CT scan was done. The data had collected in a pre designed data collection sheet.