Background: Cardiovascular disease (CVD) is a major health problem worldwide. Cardiac rehabilitation (CR) is mainly involved with secondary prevention which relies on early detection of the disease process and application of interventions to prevent the progression of disease. These interventions include education; counseling and behavioral strategies to promote lifestyle change and modify risk factors. The aim of this study was to determine the long term effect of CR on patients with percutaneous coronary intervention (PCI). Subjects and Methods: Sixty patients of both sexes (41 men and 19 women) had been recruited from National Heart Institute, Cairo. All patients underwent PCI. They were randomly assigned to two equal groups in number.