Objective: Provide a brief review about the development of animal model of otitis media with effusion. Methods: We studied different methods of inducing otitis media with effusion in animal model published in different journals and try to point out their strong and weak points. Result: Althought different animal models had been established as model, none of them were able to explain in detail about the disease physiology in animal and further more research is needed to develop a valid animal model of otitis media with effusion. Conclusion: Otitis media is one of the most common disease in children so further detail study is needed in this disease. Till the date several animal models were established. Before the research detail study on experimental animal and experimental method is necessary for the reliable result.