The study focused on the socio economic and profitability of major fisheries enterprises in Kano State, Nigeria. The socio-economic characteristics of the stake holders along the fisheries enterprises and profitability were described. It also identified and described the marketing channel of fresh and smoked fish in the study area. Gross margin analysis to assess the profitability of the business was determined. The constraints were also described and the factors that influence customer preferences in the study area identified. Primary data were collected from 30 fishermen, 30 processors and 20 consumers using questionnaire and analyzed statistically. The result of the study showed that male dominated fishing (52.3%), while female processing (47.5%). The gross margin analysis showed profitability values of N 74,350 for fishermen during raining period.