Background: Spinal cord injury (SCI) is a multisystem injury with life-threatening complications. Bone demineralization & renal complications have serious consequences for the affected person. It is hypothesized that verticalisation along with early mobilization reduces skeletal & renal complications. Methodology: 48 subjects (36 patients+12 controls) participated in this study. The patients were divided into groups A, B & C and the controls were in Group D. Basal parameters (BP, PR, RR) were recorded and Urine samples were sent for analysis. Group A was treated with only limb exercises & Group B was given limb exercises & tilt table standing. Group C had chronic patients to visualize the longterm effect of physical rehabilitation & body’s attempt at bone mineral homeostasis on urinary parameters. Results: Significant changes were noted in the values of urine calcium, inorganic phosphate, hydroxyproline & serum enzyme alkaline phosphatase among groups A, B & C when compare with D.