The concern of this study is to explore Technical and Vocational Education as a panacea for Entrepreneurship growth and development in Nigeria. A descriptive research of the survey type was adopted and three research questions were raised in the study which were tested at 0.05 alpha level of significance, the population was made up of all Technical College students in Southwest Nigeria. 480 students partook in the study, stratified random sampling was adopted to select the subjects used. A structured questionnaire and a checklist developed by the researcher were used for data collection. The instruments used were subjected to face and content validation by relevant experts, a reliability coefficient of 0.84 was obtained using test-retest method and therefore found to be reliable, a reliability coefficient of 0.80 was however obtained for the checklist. Descriptive statistical method of frequency counts and simple percentages were employed in the analysis of data generated for the study. Some of the findings of the study are: that there are adequate technical colleges in southwest Nigeria; much of the available equipment in these technical colleges are either obsolete or dysfunctional; there is also a shortage of qualified and experienced teachers and instructors. It was therefore recommended that there should be provision of modern and state of the art equipment, while dysfunctional ones should be refurbished; that there should be immediate recruitment of well trained experienced teachers and instructors with the most relevant qualification; IT experts should also be recruited to assist the instructors in training students in various subjects taken and programmes offered.