In this paper, the application of artificial neural network, Angstrom-Prescott and multiple regressions models to study the estimation of global solar radiation in Warri, Nigeria for a time period of seventeen years were carried out. Our study based on Multi-Layer Perceptron (MLP) of artificial neural network was trained and tested using seventeen years (1991-2007) meteorological data. The error results and statistical analysis shows that MLP network has the minimum forecasting error and can be considered as a better model to estimate global solar radiation in Warri compare to the estimation from multiple regressions and Angstrom-Prescott models.