The study of computer science and information systems requires commitment and dedication. Students must learn above and beyond the standard requirements in order to compete in the job market. Hence the motivation is the major driver to accomplish such requirements. This paper investigates the possible factors affecting students’ motivation at Computer Science and Information System College in Najran University. To find the best ways to improve student performance, academic planning, and improve college performance in general was behind the reason for the authors to study the motivation factors. Fifty undergraduate students from a computer and information college participated in this research. The students completed Academic Intrinsic Motivation Questionnaire (MSLQ) questionnaires. In addition, instructors answered interview questions related to factors affecting their students’ motivation. Instructors who participated in seminars and interview believes the English language is the major barrier affecting motivation. In addition, instructors believes incentives and strict regulation may help improving students’ motivation. Adding to incentives, the sense of completion is missing beside no enough recognition from college and instructors. The survey results shows students agreed that the Needs and Mastery factors motivate them. Whilst the students wasn’t able to decide on Power, Fear, Authority, and Peers motivation factors. The paper provides recommendations for college leaders and instructors on best ways to improve students’ motivation in order to reach better performance.