In this study the nutritional and anti-nutritional status of yellow, white and orange fleshed sweet potato varieties (Ipomoea batatas L. Lam) in their raw roots unpeeled and peeled were determined. The nutritional and anti-nutritional values of three sweet potato varieties were significantly (p<0.05) varied due to cultivar variation, processing conditions and their interaction. Orange sweet potato variety contains the highest level of moisture, fat, ash, carbohydrate, energy, calcium and iron in unpeeled condition and fiber, moisture, fat, ash, calcium, iron and zinc in peeled condition. On the other hand, yellow sweet potato variety contains the highest level of protein, phytate, phytate: calcium, phytate: iron and phytate: zinc molar ratios in both unpeeled and peeled conditions while the highest value of fiber, oxalate and tannin in unpeeled condition.