Purpose: The aim of this study was to evaluate the flexural strength of a veneered zirconia system after different surface treatments as a pre-cementation procedure and before veneering. Methods: Translucent Y-TZP ceramic bars, for four-point bend testing, were prepared and divided considering the compressive (surface treatment for cementation) and lower tensile surfaces (surface treatment for veneering). Two different surface treatments were evaluated: 1- glass interlayer; 2- sandblasting + glass interlayer. Four-point bending test data were statistically analyzed using ANOVA. Results: The flexural strength was significantly affected by sandblasting the surface for cementation. Sandblasting + glass interlayer on the surface for veneering combined with sandblasting the surface for cementation presented the highest flexural strength and better strength reliability. Conclusion: Sandblasting + glass interlayer on the surface for veneering combined with sandblasting the surface for cementation presented better results regarding flexural strength and reliability.