Aim : To study the curative effect of Sapindus mukorossi and Rheum emodi extracts in CCl4 induced liver cirrhosis in male rats. Methods : The dried powder of S. mukorossi & R. emodi was extracted successively with petroleum ether, benzene, chloroform and ethanol and concentrated in vacuum. The curative effect of the extracts of the fruit pericarp of S. mukorossi and rhizomes of R. emodi was studied using CCl4 induced liver cirrhosis in male rats. Biochemical parameters including serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and alkaline phosphatase (ALP) in serum were analyzed. The biochemical findings were supplemented with histopathological examination of rat liver sections. Results: Extracts of the fruit pericarp of S. mukorossi (2.5mg/mL) and rhizomes of R. emodi (3.0 mg/mL) protected the rats from CCl4 induced liver cirrhosis as judged from histopathological evidences and serum marker enzyme activities. Conclusion: We can conclude from this study, that the extracts’ of S. mukorossi and R. emodi can cure the CCl4 induced liver cirrhosis in male rats.