B: Pharma, Drug Discovery, Toxicology & Medicine (132)
GJMR: B
Formulation of Verapamil Hydrochloride Matrix Granules by Sintering Technique and its Evaluation
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 1
Exploration of sintering concept in the pharmaceutical sciences is relatively recent. The aim of this study was to investigate the release characteristics of matrix granules consisting of hydrophobic ( i.e waxy ) material and Verapamil hydrochloride for sustained release application using thermal sintering technique. It was considered as an ideal drug for designing sustained release form...
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Authors R.R. Bhagwat, Dr. I.S. VaidyaRead Journal Click Here
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Page No. 1 to 4
Pharmacological Activity and Chemical Constituents of Eclipta Alba
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
Eclipta alba is a herb commonly found throughout India. This plant is known to have various pharmacological activities and is traditionally used in treatment but it lacks adequate scientific proof of this activity and constituents responsible for it. The present paper describes the phytochemical and pharma-cological investigations of Eclipta alba. ...
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Authors Dharmender Jaglan, Amandeep Singh Brar, Rupamjot GillRead Journal Click Here
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Page No. 35 to 40
In Vitro Antidiabetic Activity of Cardiospermum Halicacabum leaves Extracts
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
Objective: The present study was designed to investigate the glucose uptake of (antidiabetic activity) crude n-hexane,ethanol, methanol and aqueous leaf extracts of Cardiospermum Halicacabum. Methods: of Cardiospermum Halicacabumleaf extracts were subjected to inhibitory effect of glucose utilization using specific standard in vitro procedure. Results: results in four different leaf extr...
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Authors Stalin.C, Vivekanandan.K, Bhavya.ERead Journal Click Here
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Page No. 41 to 43
Synthesis and Evaluation of Quinazolinone Derivatives for Cardiovascular Activity
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
Synthesis and evaluation of 3-(p methoxybenzylidene) hydrazinoacetylamino-2-methyl-6- bromoquinazolin-4-(3H)-one and 3-(p-N, N-dimethylbenzylidenylamino)hydrazine-acetylamino-2-methyi-quina-zolin-4 (3H)-one for cardiovascular activity. ...
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Authors Navneet Singh, R C Agarwal, C P SinghRead Journal Click Here
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Page No. 45 to 50
Neurotoxic Syndromes Sequencially Occuring after Consumption of Organophosphorus Compound - A Case Report
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
Organo-phosphorus compounds (OPC) are among the most used poisons for suicide in India, and associated toxic syndromes are well described. We report a young man who presented to us with alleged consumption of chlorpyrifos, a crystalline organophosphate insecticide. During hospitalization he developed acute organo-phosphorus toxicity (type I) and intermediate syndrome (type II), both situ...
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Authors Peter George, Narasimha HegdeRead Journal Click Here
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Page No. 51 to 53
Natural Antioxidants and their Intrinsic Worth for Wellbeing
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
Free radicals produced on exposure to sunlight, Xrays, ozone, tobacco smoke, automobile exhaust, environmental pollutants, and by several other physiological processes, are highly reactive and can damage nucleic acids, proteins, lipids and carbohydrates that subsequently affect the immune functioning causing degenerative diseases. In a normal cell there is an appropriate balance between ...
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Authors Bina Rani,Raaz K MaheshwariRead Journal Click Here
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Page No. 53 to 69
Drug-like Properties of Some Esters of ortho-/meta-/para-Alkoxyphenylcarbamic Acid Containing N-Phenylpiperazine Fragment
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
In recent years, in silico pharmaceutical tools have a notable impact of drug discovery as complementary methods for in vitro and in vivo assays. Such procedures help to optimize pharmacokinetic and pharmaceutical properties of (not only) drug-like candidates. Following the Lipinski´s Rule of Five concept and experimental partition coefficients data as well, the majority of curre...
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Authors Ivan Malu00c3u00adkRead Journal Click Here
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Page No. 25 to 29
Colourimetric Assay of Atomoxetine Hydrochloride by Simple Aurum Coupling Reaction in Bulk and TabletDosage Form
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
Simple, rapid and sensitive spectrophotometric procedure was developed for the analysis of atomoxetine hydrochloride (ATH) in pure form as well as in pharmaceutical formulations. The method was based on the reaction of ATH with gold (III) chloride in the pH range 3.5-4.5 forming violet colored complex solution, showing absorption maxima at 550 nm. The linear plot indicates that Beerâ...
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Authors B. Mohammed Ishaq, Hindustan Abdul Ahad, Shaik Muneer, S. PraveenaRead Journal Click Here
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Page No. 71 to 74
Unani Description of Sumaq (Rhus Coriaria Linn.) and it’s Scientific Report
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
Plants have played a vital role in the prevention and treatment of diseases since prehistoric times. WHO estimates that 65%-80% of the world’s population use traditional medicines, as their primary form of health care and most of the diseases have been treated by administration of plant or plant products. Sumaq (Rhus coriaria Linn.) is most useful herbal medicinal plant ...
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Authors Haqeeq Ahmad, Faiyaz Ahmad, Izharul Hasan, Shabbir AhmadRead Journal Click Here
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Page No. 75 to 78
Effect of Diallyl Disulphide on Protein and Lipid Glycation, and Lipid Peroxidation in Brain of Alloxan Diabetic Rats
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
Non enzymatic glycosylation of proteins and lipids is the main initiating factor for the pathophysiology of chronic diabetic complications. This glycation is more prevalent in insulin independent tissues like brain, kidney, RBCs, etc. Diallyl disulphide (DADS), the principle compound of garlic oil, is well known for its antihyperglycemic, antihyperlipidemic, anticarcinogenic and antibiot...
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Authors Vijay V,Vickram, Kashinath RTRead Journal Click Here
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Page No. 9 to 13
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Sequential Analysis of Postural Control Resource Allocation during a Dual Task Test
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
Objective : To investigate postural control factors influencing automatic (reflex-controlled) and attentional (high cortical) factors on dual task. Method : We used a dual-task model to examine attentional factors affecting control of posture, subjecting test subjects to vibration stimulation, one-leg standing and verbal or nonverbal task trials. Twenty-three young, healthy participants ...
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Authors Ji Hye Hwang, Chang-Hyung Lee, Hyun Jung Chang, Dae- Sung ParkRead Journal Click Here
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Page No. 15 to 23
Botanical Standardization of the Embeli Ribes Burm F& Possibilities of Species Substitute
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 7
EmbeliaribesBURM. F. is an important drug of Ayurveda. Which is considered as multi remedies *with wide* group of Active consistents.Isolated from the berries. Because of High Commerce, Traders, are subjected to 26 species of substitution, a detailed botanical investigation with macro & microscopical comparison with the drug used under the name of VIDANGA. Therefore the present study is ...
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Authors Syed Asadulla, Ramandang, RajasekharanRead Journal Click Here
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Page No. 31 to 34
College Students on Antidepressants
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 6
Depression has been increasingly diagnosed in the college age population with the American College Health Association reporting 16% of all college students having been diagnosed with depression.1 In another large survey of American college students, over half reported some depressive symptoms since entering college.2 Correspondingly, the percentage of all people treated with antidepressa...
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Authors Aselton, Pamela JRead Journal Click Here
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Page No. 27 to 31
Chemistry, Pharmacology and Medicinal Property of Sage as a Viable Agent in the Treatment of Prostate, Pancreatic or other Types of Cancer
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 13 Issue: 6
Sage (Salvia) species is known as the Functional Novel Natural Medicine, Salvia Extract are considered important for drug development, because they are reported to have Pharmacological activity in the Asia, Middle East especially China and India. For a long time Salvia has been used in traditional medicine for the relief of pain, protecting the body against oxidative stress, free radical...
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Authors Rafie Hamidpour, Soheila Hamidpour, Mohsen Hamidpour, Mina ShahlariRead Journal Click Here
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Page No. 11 to 19
