A 61 years old woman with dizziness and gait disturbance in relation to brain metastases of a rectal adenocarcinoma (cT3N1M1). CT showed an unique frontal lesion and no further disease in other organs. Performance Status 1, so Digestive Tumors Committee decides surgical treatment of frontal brain metastasis and the histologic postsurgical examination showed microscopic affected margins. Then, radiation therapy (RT) of brain with radiosurgery and short course 5x5 of the primary tumor with low anterior resection was completed. After 2 months of brain RT, liver progression was discovered and then we decided neoadjuvant chemotherapy mFOLFOX6 and bevacizumab x 5 cycles with stable liver metastases and no other lesions. Following, limited liver resection and adjuvant chemotherapy was performed with the same schedule. No signs of tumor recurrence and more than 13 and 24 months of disease-free survival (DFS) and overall survival (OS) respectively was achieved in a metastasic cancer (brain metastasis) with usually OS 3 months.

This paper approaches a technique that help to find and diagnosing faults in transmission lines using image process technique. Image processing technique is widely used in all area for solving the problems. In this paper, Digital image processing wavelet shrinkage function is use for fault identification and diagnosis. In the other word, take a faulty image from the source like thermo vision camera and real time recording instrument with the co-ordinates of transmission line. Uses the algorithm of digital image processing for segmentation of the image, segmentation divides the image in set of parts and objects, and then apply the wavelet shrinkage function to read the image and give the result. The proposed method provides results that are in terms of PSNR and visual quality.

Concretions are small white or yellowish dots, usually less than 1mm in diameter, commonly seen on the undersides of the eyelids. They contain cell debris and calcium. They may be the result of past inflammation. Occasionally they cause irritation. If concretions are causing symptoms, the opthalmologist intend to remove them. After using anaesthetic drop, concretions can usually be teased out with the tip of a hypodermic needle. In the case chosen in our study the patient has been suffering from ocular discomfort BE since 5 yrs gradually that patients complaint has been increasing in spite of using all the allopathic medicines as prescribed by the doctor. So here in our study triphala parishek is tried for 10 days in three sittings with gap of 10 days and patient got complete and gradual relief from the symptoms in duration of 2 months.

Participatory approaches such as participatory plant breeding (PPB) and participatory varietal selection (PVS) have become a motivating force for agricultural research and rural development. These approaches have been developed over the past decades as an alternative to centralised breeding methods designed to better incorporate the perspective of end users into the varietal development process to efficiently address the desires of the farmers for increasing food security and improving livelihoods of farmers, especially in resource poor areas. In search of this concept, this review paper discusses the concepts, advantages, experiences, impact and challenges in these participatory approaches stressing the existing evidence of success by various authorities from different countries. In PPB, farmers are actively involved in the breeding process, from setting goals to selecting variable, early generation material. In PVS, farmers are given a wide range of new cultivars to test for themselves in their own fields. In some of the crops the genotypes selected by the breeder and farmers were almost similar but some differences existed. Since participatory approaches include research and extension methods to deploy genetic materials at on farm experiment so that the variety developed through PPB and PVS remarkably increased varietal diversity that can meet demand of different stakeholders. It could be concluded that, the benefits of participatory research approach includes development of farmers’ ownership of new technologies being tested and transferred; increasing degree of farmers’ awareness, increase varietal diversity and mobilization of farmers’ indigenous knowledge available within local communities for research and development planning and empowerment. Various authors’ indicated that participatory approach is a dominant way to involve farmers for selecting and testing new cultivars that are adapted to their needs, systems and environments. Therefore, for susta

Eight tef varieties including local checks were evaluated with the objective of selecting adaptable, best performing varieties and to assess farmers’ criteria for tef variety selection during 2008 and 2009 cropping season at Areka and Hossana stations of Areka Agricultural Research center in the Southern region of Ethiopia. In the study the Tef varieties namely Koye, Gimbichu, Quncho, Dega tef, Keytena, Amarach and Ajora-1 were collected from the Federal and regional Research center along with local checks, Ethiopia and Regional Agricultural Research Institute. These materials were put into trial at Areka Agricultural Research center station farms at Areka and Hossana of Wolayta and Hadiya Zones. The trial was laid out in a randomized complete block design with three replications. Each plot measured 3m x 3m with 1m between plots and 1.5m between blocks. Sowing was done within the last week of July to 1st week of August 2008 and 2009. Data on various characters, such as plant height, panicle length, days to heading, and days to maturity and grain yield. Data was subjected to analysis of variance and there was highly significant difference (p<0.01) among the varieties for grain yield and some of agronomic traits. The results for the trials indicated that there were significant yield differences between the local check and the released varieties at two stations. At Areka, the combined analysis of variance over years indicated that varieties Koye, Amarch and Quncho gave the highest grain yield viz., 988.7, 984.3 and 958.7 kg/ha respectively. Similarly at Hosanna, varieties Gimbichu, Quncho and koye out yielded other varieties and had yield advantage of 31.9, 25.14 and 15.14 % over local variety, respectively. Both combined across locations over year’s analysis and farmers’ assessments identified two varieties Quncho and Koye as potential varieties for wider production. This result also indicated that farmers were as capable as Researchers in varietal choice. There

The background: Is to detection of intron 22 mutations in the FVIIIgene inIraqi carriers in Wasit city with hemophilia A which is an X- chromosome linked recessive bleeding disorders caused by defect of the clotting factor VIII (FVIII), mainly related to F8 mutations which intron 22 inversion is the most common mutations type that occur in hemophilia over the worldt hat about half of the patients with severe hemophilia A have this mutations and by intron 1 inversion in 5% of the patients with severe HA. Both inversion mutations occur only in male and rare in females as a result of intrachromosomal recombination between homologous regions, in intron 1 or 22, and their extragenic copy located telomeric to the FVIII gene. Unfortunately regrettably in Iraq no studies were done regarding hemophilia gene detection in carriers with intron22 mutations barring this study. Aims of study: Detection analyze the presence of intron 22 mutations in the FVIII gene in 10 HA Iraqi carriers families with Importantly, there is a small risk for recurrence even when the familial F8 mutation is not identified in the mother of the affected patient due to the possibility of germline mosaicism in the community. Patients and Methods: This study included 10 Iraqi carriers with hemophilia A and 5 healthy members as control. This work done in medicine & science college laboratories as well as AL Karama Teaching Hospital from November, 2016 to January, 2017. These carriers previously diagnosed by family history, DNA testing. Results: During the screening for Inv22 (intron 22 inversions) among the HA carriers, results showed 4 (40%) from 10 carriers had this mutations. Discussion: Our data highlight the prominence of the analysis of Inv22 for their association with positive family history in the HA carriers and we are continuous searching of Inv1 mutations. Conclusions: Results indicate the bad effect of positive family history and the consanguinity marriage. Carriers of haemophilia A require spec

In many cases, it might be advisable to keep an operational time series model fixed for a given span of time, instead of updating it as a new datum becomes available. One common case, is represented by model–based deseasonalization procedures, whose time series models are updated on a regular basis by National Statistical Offices. In fact, in order to minimize the extent of the revisions and grant a greater stability of the already released figures, the interval in between two updating processes is kept "reasonably" long (e.g. one year). Other cases can be found in many contexts, e.g. in engineering for structural reliability analysis or in all those cases where model re–estimation is not a practical or even a viable options, e.g. due to time constraints or computational issues. Clearly, the inevitable trade–off between a fixed models and its updated counterpart, e.g. in terms of fitting performances, out–of–sample prediction capabilities or dynamics explanation should be always accounted for. This paper is devoted at presenting a procedure for the prediction of the loss in terms of fitting ability of a fixed model of the type autoregressive integrated moving average versus its updated version – according to a suitable quadratic cost function – and at giving a quantitative measure of the discrepancy between them. Being the updating frequency customizable, the presented approach can also be employed for simulations purposes, according to the updating intervals, the degree of complexity of the chosen model and the available computing resources. Finally, an empirical experiment involving both computer simulated and macroeconomic time series will be presented and the related outcomes discussed.

Many studies have empirically shown that multimarket contact (MMC) has collusive effects in the US airline industry. The US airline industry has recently undergone large changes. For example, some airlines have implemented mergers and acquisitions (M&A), while Low-cost carriers (LCCs) have matured over time and developed according to multiple business models. Few previous empirical studies of MMC have taken these changes into account. Thus, this paper analyzes the impact of M&A on the effects of MMC while taking into consideration the presence of LCCs. We focus on Southwest’s “acquisition of Airtran Airways and estimate the simultaneous demand and price equations using unbalanced panel data for the fourth quarters of 2009, 2010, 2011, 2012, 2013 and 2014. We madethree findings. First, MMC has collusive effects on airlines’ pricing in the US airline industry. Second, the effect of MMC on Southwest Airlines’ pricing did not increase after the acquisition of Airtran Airways. Third, Southwest Airlines’ rivals may show more collusive effects of MMC after an acquisition is made by Southwest Airlines.

There have been discourses on the issues of health care differences between the developing and developed world and the need to bridge the health care divide or the provision of health care services for all countries. A case study between Haiti and Harvard highlighted the poor and good state of health care system as it relates to causes of death. Though, universal health care is high and unsustainable as a result of several militating factors including cost and politics, cost is not as important as saving a life, recognizing human rights, resources for economic productivity, lowering the cost of health care, which implies that every hand must be on deck including the government, individuals, organizations and other richer countries to help develop a good health care system. Hence, the debate of sustainability health care system or universal health care is based on the matter of social, political and economic sustainability and policymaking.

Wireless Sensor Networks (WSNs) are characterized by multi-hop wireless connectivity, frequently changing network topology and need for efficient routing protocols. The purpose of this paper is to evaluate performance of routing protocolDSDV in wireless sensor network (WSN) scales regarding the End-to-End delay and throughput PDR withmobility factor .Routing protocols are a critical aspect to performance in mobile wireless networks and play crucial role in determining network performance in terms of packet delivery fraction, end-to-end delay and packet loss. Destination-sequenced distance vector (DSDV) protocol is a proactive protocol depending on routing tables which are maintained at each node. The routing protocol should detect and maintain optimal route(s) between source and destination nodes. In this paper, we present application of DSDV in WSN as extend to our pervious studyto the design and implementation the details of the DSDV routing protocol in MANET using the ns-2 network simulator. also, the performance of DSDV protocol in sensor network of randomly distributed mobile nodes with mobile source and sink nodes is investigated for MAC IEEE802.15.4 network by ns-2 simulator..