The present study deals with comparative evaluation of hepatoprotective activities of Melia azedarach Linn, Catharanthus Rosea and Brassica oleracea L.var.capitata ethanolic leaves extracts against simvastatin induced hepatotoxicity in rats. Hepatotoxicity in rats was induced by simvastatin (20 mg/kg p.o. for 30 days) and the protective effect of Melia azedarach Linn, Catharanthus Rosea and Brassica oleracea L.var.capitata (300 mg/kg/p.o. and 500 mg/kg/p.o.) was identified by estimating marker enzymes. Simvastatin treated rats shows significant changes in biochemical parameters i.e. increases in Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alanine Phosphatase (ALP), Serum bilirubin and decrease in Total proteins content, which were restored towards normalization in extracts treated rats. The results revealed that the ethanolic extracts of Melia azedarach Linn, and Brassica oleracea L.var.capitata (300 mg/kg/p.o. and 500 mg/kg/p.o.) exhibited potent hepatoprotective activity than Catharanthus Rosea. The hepatoprotective effect of extracts was further confirmed by histopathological studies of liver, which shows normal architecture of liver cell than compared with hepatotoxicant group. Possible mechanism for hepatoprotective activity may be due to free radical scavenging potential in extracts.