A large number of multi-storey reinforced concrete (R/C) framed building structures in urban India are constructed with masonry in fills for architectural, aesthetic or economic reasons. We have investigated the effect of the layout of masonry infill panels over the elevation of masonry in filled R/C frames on the seismic performance and potential seismic damage of the frame under strong ground motions using nonlinear static push-over analysis based on realistic and efficient computational models. From output non-linear analysis, we compare Base shear and Displacement in bare frame, in fill wall frame and ground, it seen that at roof level, displacement in bare frame is more than other two frames and displacement at ground floor in weak story is more than other two frames. Mostly hinges are formed in beam than in column.