Background: Snake bite is predominantly an occupational hazard and a common cause of morbidity and mortality. Acute renal failure has been associated with venomous viper and sea snake bites. AIMS: This study was carried out to study the incidence and clinical profile of the snake bite patients who develop acute renal failure;and to identify the predictors of morbidity and mortality in these patients. Material and methodology: We carried out prospective study on fifty (50) cases of definitive snake bite admitted to Department of Medicine/Emergency medicine, Kempegowda institute of medical sciences, Bangalore from May 2012 to November 2013. Statistical analysis: SPSS for Windows version 17.0 (SPSS, Inc, Chicago, Ill) was used for statistical analysis. The Pearson Chi-Square Test was used to analyze parametric variables. A P value of 0.05 or less was considered statistically significant.