Spatial Multiplexing (SM), which employs multiple antennas at transmitter as well as at receiving side, is mainly responsible for the spectral efficiency enhancement in MIMO (Multiple Input Multiple Output) systems without additional bandwidth and power requirement. In this paper, MIMO Spatial Multiplexing technique is analyzed for different antenna configurations (2×2, 3×3, 4×4) in AWGN (Additive White Gaussian Noise) channel using higher order modulation techniques (M-PSK, M-QAM). The Zero Forcing detector is employed at the receiving end. The performance of MIMO SM technique is compared for different antenna configurations and simulated results shows that 0-2 db increment in SNR (Signal to Noise ratio) is required if antenna configuration is changed from 2×2 to 3×3 and 0-3 db increment in SNR is required if antenna configurations are changed from 3×3 to 4×4.