Keeping in view the paucity of information related to inferior phrenic arteries, the present study has been carried out to provide a detailed account of variation in the mode of origin of inferior phrenic artery. The study was carried out on 30 adult human cadavers of known sex. On the right side, the inferior phrenic artery arose independently in 20 cases (66.6%) and by a common trunk in 10 cases (33.3%). On the left side the artery arose independently in 20 cases (66.6%) and by a common trunk in 10 cases (33.3%). The renal artery was seen as the source of the inferior phrenic artery on 3 sides. The inferior phrenic artery usually originates from the aorta or celiac trunk and less frequently from the renal, hepatic or left gastric arteries. This artery is a major source of collateral or parasitized arterial supply to hepatocellular carcinoma, second only to the hepatic artery. Recognition of variations enables clinicians to distinguish features which merit further investigations or treatment from those which do not .Clinical implications of variations in this artery have been stressed upon.