Objective: To evaluate the clinical and laboratory profile of dengue in the central Karnataka region of South India. Materials and Methods: It is a prospective study was carried out between July-October, 2013 in BMCH & RC in central Karnataka. The study included seropositive dengue fever inpatients admitted in the medical wards in the age group of 18- 75 yrs. The test kit used for the sero diagnosis of dengue was “Dengue day 1 test kit (J. Mitra & co. Pvt. Ltd.)” which shows NS1, IgM and IgG reactivity towards dengue fever. Result: Out of 146 seropositive cases, 92 were males and 54 were females. Most of the cases reported in young age groups (i.e. 20-30 years) compared to other age groups. NS1 antigen, IgM and IgG antibody was found reactive in 112 (76.71%), 2 (1.36%) and 6 (4.10%) patients respectively. The commonest presenting clinical symptoms in patients are fever (in all patients, 100%), severe headache (n=110, 75.34%), Nausea/Vomiting (n=84, 57.53%) and Fatigue (n=68, 46.57%). The bleeding manifestations were found in 14 patients (9.58%) which includes Gum bleeding, Hematuria, Hematemesis and Malena. Bleeding manifestations was associated with severe thrombocytopenia, were in 33.33% of patients. Discussion: Early recognition and prompt management is essential to reduce the morbidity and mortality associated with disease.