Background: The main goal in diabetes care is to improve the patient’s quality of life, to maintain satisfactory metabolic control and to retain minimal complications caused by diabetes mellitus (DM). To accomplish these goals, selfcare has a great role. However, most patients don’t control their blood sugar label. The objective of this study was to investigate status of glycemic control and self-care practice among Ambulatory diabetes patients in Ambo General Hospital. Method: Cross-sectional study was conducted from 01 February to 30 May 30/ 2014. Sample population includes all diabetes patients who will come for checkup during data collection period. The data was collected with structured questionnaires and check list by trained data collectors. Data was cleaned and analyzed using SPSS version 20.