Sepsis is a systemic inflammatory response syndrome: clinical inflammatory response to disturbances that cause infection or not infection1. Patient entered in the Emergency Room (ER) 8 October 2014, the diagnosis of sepsis patient ec furnier gangrene (scrotum), Haematemesis ec gastropathy uremikum, CKD stage V on HD with anemia, metabolic acidosis, CHF fc II, type II diabetes mellitus, hypertension, hepatitis B therapy received treatment for at GatotSubroto Army Hospital namely, Lasix, D40%, Insulin (Novorapid, Humalog), Meropenem, Levofloxacin, Farmadol, Omeprazole, Transamin, Vitamin K, Sodium Bicarbonate, Calcium Carbonate, Folic Acid, Vitamin B12, Valsartan, Amlodipine, Transfusion Package Red Cells (PRC), Triofusin e 1000, Tramal, Ca Gluconate, Metronidazole, Cefoperazone Sulbactam, Albumin transfusion, transfusion Fresh Frozen Plasma (FFP), the result of monitoring drug therapy patient obtained their multiple DRPs (Drug Related Problems), correlation between therapy with disease, Selection of appropriate medication, dosage regimen, interactions and contraindications.