Objective:To investigate the histological changes in the skin tissue covering the area surrounding the ulceration of the diabetic foot. Patients & Methods: The study was performed on 30 patients who were classified into 3 groups 10 patient in each. Group I is the control group have no diabetes, group II with diabetes mellitus type I, and Group III patients with diabetes mellitus type II. All the diabetic patients showed various degrees of skin lesions in the foot. Specimens of skin tissue were obtained from the area surrounding the diabetic ulcer from Al-Jumhuri Teaching Hospital and the histological analysis was performed in the Department of Anatomy, College of Medicine, University of Mosul from November 2015 to June 2016. The specimens were processed for the standard histological examination using Hematoxylin and Eosin, and Orcein-VanGieson stains. Results: The skin sections were dominated by the presence of hyperkeratosis in the epidermis with regular acanthosis in addition to dense chronic inflammatory cells infiltration in the dermis, absence or degeneration of the sweat glands, perivascular lymphocytic infiltration ,focal areas of necrosis and melanin pigmentation in the dermis. The large arterioles and arteries of muscular type revealed fibrous tissue deposition at the level of media while the peripheral nerves showed an obvious degeneration of Schwann cells. Conclusions: The vascular changes in the diabetic foot appears in the microcirculation level (capillaries) then involves arterioles and arteries of muscular type and were accompanied by morphological changes of the Ù£ peripheral nerves.The morphological changes in the skin surrounding the diabetic foot ulcer involves both the epidermis and dermis. The identification of histological and vascular alterations in the diabetic foot allows more knowledge related to the pathogenesis and pathological background of this condition.