B: Pharma, Drug Discovery, Toxicology & Medicine (132)
GJMR: B
Delivery of Macromolecular Drugs using Microsphere Technology
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 15 Issue: 2
Resent years have witnessed development of protein- based therapeutic agent as the main focus of biotechnology industry. Progress made in biotechnology, genomics and combinatorial chemistry have led to the discovery of a wide variety of active moiety for specific therapeutics application. However, the common problems associated with these active moieties such as poor stability, low solub...
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Authors Sabna B, Sijo Pattam, Vimal Mathew, Sujith VarmaRead Journal Click Here
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Page No. 1 to 5
Non Adherence and its Contributing Factors to Anti-TB Drug in Children’s at Adama Referral Hospital, Oromia, Ethiopia
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 15 Issue: 2
Objective: The objective of this study was to assess of factors affecting adherence of pediatric TB patients to anti TB drugs in Adama referral hospital. Methodology: Retrospective cross sectional study has been conducted from March 19th to May 20th, 2014 to assess factors affecting adherence of pediatrics TB patients to anti TB drugs in Adama referral hospital. Data collection format wa...
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Authors Kelifa Osman Yusuf, Muluneh Fromsa Seifu , Belayneh Kefale Gelaw, Esayas Tadesse Gebremariam, Mustefa Ahmed MohammedRead Journal Click Here
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Page No. 11 to 18
Marijuana: Neurotoxic or Neuroprotective?
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 15 Issue: 2
Chronic marijuana intake was known to induce morphological changes to the brain impairing memory and learning ability. However, several studies demonstrated the protective effect of marijuana post-brain traumas. This article reviews studies that strengthen our horizon to understand the effects of marijuana smoking in brain. This review predicts that optimum use of marijuana or pure marij...
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Authors Manoj BanjaraRead Journal Click Here
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Page No. 7 to 10
Evaluation of Anti-Angiogenic Effect of Naturally Occurring Compound from Ficus.Bengalensis on Regeneration & Development of Zebra-Fish Fin
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 15 Issue: 1
Angiogenesis is the process that leads to the formation of new blood vessels or neovascularisation. Angiogenesis inhibitors are designed to prevent the formation of new blood vessels. The main aim of this study is to evaluate Anthocyanin obtained from medicinal plant Ficus.bengalensis for Anti-angiogenesis & to standardize a method for the study of angiogenesis. A variety of animal model...
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Authors Uday P Kundap, Dr Sadhana Sathaye, Rachana D Sarawade, Dr. Ketan Patel, Pankaj D JainRead Journal Click Here
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Page No. 9 to 19
Comparative Antimicrobial Activity of Ethanol and Hexane Leaf Extracts of Ficus Exasperata on Five Microbial Isolates
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 15 Issue: 1
This study evaluated the antimicrobial activity of Ficus exasperata and compared the efficacy of ethanol and hexane extracts on five microbial isolates. To ascertain the set objective, after extraction with ethanol and hexane, the disk and well diffusion agar methods were employed to investigate the antimicrobial activity of the extracts and its minimum inhibitory and bactericidal concen...
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Authors Godwill Azeh Engwa, Richard N. Tagbo, Chinedu Chukwuekezie, Marcellus Unaegbu, Marian N. UnachukwuRead Journal Click Here
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Page No. 21 to 28
Antibiotics Utilization and their Cost in Ayder Referral Hospital, Mekelle, Ethiopia
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 15 Issue: 1
Inappropriate use of antibiotics can potentially lead to antimicrobial resistance and increase the necessity to use more expensive antibiotics to treat common and life threatening infections. The major goal of this research was to determine antibiotics utilization and their cost among in-patients treated in Ayder Referral Hospital. An institution based cross-sectional study was conducted...
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Authors Solomon Abrha, Rahel Assefa, Fantahun Molla, Wondim Melkam, Admassu Assen, Anwar Mulugeta, Abrham Wondimu, Jemal Mohammed, Birhanetensae MasreshaRead Journal Click Here
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Page No. 1 to 7
An Assessment of Adherence of Patients to Anti-Hypertensive Medication and Factors for Non-Adherence in Oromia Region Adama Referral Hospital, Ethiopia
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 15 Issue: 1
Background: Hypertension (HTN), or high blood pressure (systolic blood pressure >140 mmHg and diastolic blood pressure >90 mmHg) is an overwhelming global challenge which ranks third as a cause of disability-adjusted life-year. Hypertension causes 7.1 million premature deaths each year worldwide and accounts for 13% of all deaths globally. There are effective medical therapies for hypert...
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Authors RRemedan Anuwer, Muluneh Fromsa Seifu, Belayneh Kefale Gelaw, Thirumurgan Gunasekaran, Esayas Tadesse Gebremariam, Mustefa Ahmed MohammedRead Journal Click Here
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Page No. 29 to 36
Problems of using Hydrochlorothiazide Diuretic in Adult Diabetic Patient in Diabetic Clinic of Adama Hospital Medical College,East Shoa Zone ,Oromia Regional State, Ethiopia
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 15 Issue: 2
Back ground: Diabetes mellitus (DM) is a group of common metabolic disorders that share the phenotype of hyperglycemia. Half century ago hydrochlorothiazide has been associated with a diagnosis of diabetes in hypertension treatment containing hydrochlorothiazide during long term therapy. This explained by association between glucose, potassium, and hydrochlorothiazide induced hyperglycem...
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Authors Omer Aliyi, Mohammed Hussien,Belayneh KefaleRead Journal Click Here
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Page No. 35 to 41
Assessment of Knowledge, Attitude and Practices Regarding Life Style Modification among Type 2Diabetic Mellitus Patients Attending Adama Hospital Medical College, Oromia Region, Ethiopia
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 7
Background: The person with diabetes mellitus has a chronic lifelong disease, the person must be knowledgeable to coordinate life style modification in to a daily routine of work to achieve and maintain normal physiological blood glucose level. The objective of this study was to determine the knowledge, attitude and practices of LSM management of type 2 diabetic patients in Adama Medical...
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Authors Esayas Tadesse, Abdulkadir Mustefa Adem, Belayneh Kefale Gelaw, Mustefa Ahmed, Muluneh Fromsa Seifu, Dr. Thirumurugan G.Read Journal Click Here
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Page No. 37 to 48
Glycemic Control and Self-Care Practice among Ambulatory Diabetic Patients in Ambo General Hospital, West Showa, Ethiopia
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 7
Background: The main goal in diabetes care is to improve the patient’s quality of life, to maintain satisfactory metabolic control and to retain minimal complications caused by diabetes mellitus (DM). To accomplish these goals, selfcare has a great role. However, most patients don’t control their blood sugar label. The objective of this study was to inve...
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Authors Gobezie Temesgen Tegegne, Awoke Shiferaw, Belayneh Kefale Gelaw, Amsalu Degu Defersha, Minyahil Alebachew Woldu, Jimma Likisa LinjesaRead Journal Click Here
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Page No. 27 to 36
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In Vivo Anti-Inflammatory and in Vitro Antioxidant Activities of Toona Ciliata Leaves Native to Bangladesh
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 7
The study was performed to assess the antiinflammatory, antioxidant activities and identify the polyphenols of Toona ciliata grown in Bangladesh. Antiinflammatory activity was examined by the methods of carrageenan and histamine-induced paw edema. At the dose of 400 mg/kg, effective anti-inflammatory activity (P<0.01) was observed in rats for both the test models of carrageenan and hista...
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Authors Hemayet Hossain, Proity Nayeeb Akbar, Shaikh Emdadur Rahman, Tanzir Ahmed Khan, Md. Mahfuzur Rahman, Ismet Ara JahanRead Journal Click Here
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Page No. 17 to 25
Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 7
In our study we synthesized schiff’ base of sulphadiazine on treating with aromatic aldehydes like para diethyl amino benzyldehyde and paradimethyl amino benzyldehyde. The synthesized schiff’s bases were converted to its cationic amphiphilic bases by treating with methyl iodide. The cationic schiff bases were converted to metal complexes by treating with...
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Authors K.Hariprasath, I. Sudheer babu and P.Venkatesh, U.Upendra Rao.Read Journal Click Here
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Page No. 9 to 16
Anti-Ulcer Activity of Rhus Coriaria in Indomethacin and Water Immersion Restraint Induced Gastric Ulcer in Experimental Rats
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 7
The anti-ulcer activity of hydro alcoholic extract of Rhus coriaria Linn (HAERC) was investigated in Indomethacin and Water immersion-induced restraint gastric ulcer in Wistar rats. The assessment was carried out by using ulcer index, ulcer score and histopathological studies of the specimens. HAERC at doses of 145 and 248 mg/kg given orally produced significant inhibition of the gastric...
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Authors Haqeeq Ahmad, Abdul Wadud, Nasreen Jahan, Izharul HasanRead Journal Click Here
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Page No. 1 to 7
The Cardioprotective Effects of Irbesartan and Candesartan in Isoproterenol Induced Cardiomyopathy in Rats
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 6
The presence of a wide selection of angiotensin receptor blockers and the conflicting evidence regarding their cardioprotective effect, led to the attempt to evaluate the impact of irbesartan and candesartan on cardiac hypertrophy and remodeling. Female Albino rats were divided into 3 groups. The first group served as the control group and was given 1 ml distilled water via oral gavage a...
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Authors Jan J. Alshmani, Ansam N. AlhassaniRead Journal Click Here
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Page No. 17 to 21
