B: Pharma, Drug Discovery, Toxicology & Medicine (132)
GJMR: B
Correlation of Protein Carbonyl andMalondialdehyde in Oxidative Stress Induced Senescence of RBC Membrane in Type 2 Diabetes Mellitus
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 6
Diabetes mellitus is a group of metabolic disease characterised by a state of chronic hyperglycemia. The biochemical process of Advanced Glycation appears to be enhanced in the Diabetes melieu as a result of not only hyperglycemia but also other stimuli such as oxidative stress and lipid peroxidation. The aim of the study is to establish a link between the oxidative stress induced by cha...
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Authors Dr. AsfiaAfreen , Dr. Dinesh Javarappa, Dr Mohamed Murtuza KauserRead Journal Click Here
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Page No. 13 to 20
Glutathione S-Transferase Activity of Three Erythrocyte Genotypes of Human Participants Treated with Pyrimethamine/Sulphadoxine and Quinine
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 6
Studies to ascertain levels of erythrocyte glutathione S-transferase (Ery-GST) activity of non-malarious and malarious male participants of HbAA, HbAS and HbSS erythrocyte genotypes treated with pyrimethamine/sulphadoxine mixture and quinine were carried out. Incubation of erythrocytes with 1-chloro-2, 4-dinitrobenzene (CDNB) caused quantitative conjugation of reduced glutathione (GSH) t...
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Authors Paul Chidoka ChikezieRead Journal Click Here
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Page No. 5 to 12
Effect of Cabergoline Added to Metformin on Glycemic Control, Insulin Resistance and Beta Cell Function in Obese Type 2 Diabetic Patients
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 5
The aim of this study is to examine the effect of cabergoline added to metformin on glycemic control, insulin resistance and B-cell function in obese type 2 diabetic patients. Forty obese patients with newly diagnosed type2 diabetes were enrolled in this study and randomized by 1:1 ratio into group (I) receives metformin and group (II) receives metformin plus cabergoline for 12 week. We ...
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Authors Hayder Ch. Assad, Hamoudi A. Mosah, Hashim M. Hashim, Faris A. KhazaalRead Journal Click Here
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Page No. 25 to 31
Comparative Analysis of Antiglycation Capacity of Aqueous and Methanolic Extracts of Vegetables
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 6
Glycation is a reaction between amino group of blood proteins and reducing sugars in vitro conditions which are involved in a number of pathologies and disease states including Alzheimer’s and diabetes. Equal concentration of different inhibitor extracts (sweet potato, turnip and methi) and glucose were used. Eight combinations of each extract were made and all these wer...
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Authors Bilal Ahmed, Muhammad Wasim Ashraf, Abdul Ghaffar, Farah Latif, Zahid MahmoodRead Journal Click Here
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Page No. 1 to 4
Reducing Topical Mometasone Furoate Doses by Applying Hyaluronic Acid as a Skin Penetration Enhancer
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 5
The objective of the present study was to investigate the possibility to add hyaluronic acid (HA) as skin penetration enhancer to mometasone furoate (MF) to enhance its skin absorption, and so decrease the dose and side effects in different types of topical formulations including absorption ointment base, oil in water emulsion base and water in oil emulsion base in addition to alcoholic ...
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Authors Khaled Aly Khaled, Usama Farghaly Aly, Doaa Amal TawfikRead Journal Click Here
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Page No. 13 to 23
A Study of Clinical and Laboratory Profile of Dengue Fever in Tertiary Care Hospital in Central Karnataka, India
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 5
Objective: To evaluate the clinical and laboratory profile of dengue in the central Karnataka region of South India. Materials and Methods: It is a prospective study was carried out between July-October, 2013 in BMCH & RC in central Karnataka. The study included seropositive dengue fever inpatients admitted in the medical wards in the age group of 18- 75 yrs. The test kit used for the se...
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Authors Mohamed Murtuza Kauser,Kalavathi G P, Mehul Radadiya, Karthik M,Asfiya Afreen,Kumaraswamy R C, Vagesh S R,Prashanth GRead Journal Click Here
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Page No. 7 to 12
Preparation and Evaluation of Inhalable Sustained Release Sildenafil Citrate Solid Lipid Microparticles Dispersions
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 5
This is a preliminary study utilizing drug targeting approach for developing sildenafil citrate (SFC) pulmonary delivery system, a first – line for pulmonary arterial hypertension (PAH) treatment and hence reducing the dose and the side effects. The closed melt method was employed for preparing SFC – solid lipid microparticles dispersions (SFC ââ‚...
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Authors Dr. A.A. YasRead Journal Click Here
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Page No. 1 to 5
Phytochemical, Mineral Compounds and Anti-Oxidation Studies on Pistacia Lentiscus Shoot Extract
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 5
Shoot extracts of Pistacia lentiscus (P. lentiscus ) were investigated for its medicinal importance, by valorizing of some chemical characterization, mineral composition, and study of the antioxidant activity. The photochemical screening of the plants constituents were assessed by using qualitative tests were conducted for the presence of the following active components: alkaloid, Hydrol...
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Authors ELgubbi, S.H., Mlitan , M.A, Shargi, Halfawi,A.., Zorab, A.Read Journal Click Here
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Page No. 33 to 40
An Insight into the Genetic Study and Pathogenesis of the Colorectal Cancer
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 4
Colorectal cancer is defined as the cancer of the large intestine or the rectum – thus attributing to some other names related to this cancer such as – bowel cancer or rectal cancer, depending on the site where the tumor has occurred. It mostly begins as a benign tumor with then turns into a carcinoma.Colon cancer and rectal cancer are related in terms o...
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Authors Tapan Behl, Ishneet Kaur, Heena Goel, Rajesh K. PandeyRead Journal Click Here
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Page No. 29 to 36
Determinants of Under-Five Childhood Diarrhea in Kotebe Health Center, Yeka Sub City, Addis Ababa, Ethiopia: A Case Control Study
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 4
Background: It is a fact that diarrheal diseases caused major public health problem in children under-five years of age, especially in developing countries like Ethiopia. Methods: Institutional based unmatched case-control study design was conducted. A case in this study was a child under-five years of age visited Kotebe health center for treatment and a control was a child under-five ye...
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Authors Aklilu Tilahun Zeleke , Zewdie Aderaw AlemuRead Journal Click Here
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Page No. 1 to 7
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The Need of Pharmacovigilance Activities in Yemen
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 4
Adverse drug reactions, medication errors and other drug-related problems are the leading causes of hospitallisation and are associated with a huge economic burden and significant human suffering. This serious issue of medication therapy also contributes to morbidity and mortality. At present, the monitoring of adverse drug reactions was started in Yemen by establishing a pharmacovigilan...
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Authors Mohammed Ahmed AlshakkaAbdulkareem Mohammed Alshami . Mohamed Izham Mohamed IbrahimMohamed Azmi Hassali, Alian Alresheedy, Saleh Altamimi, Saleh AlgfrIRead Journal Click Here
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Page No. 9 to 13
Analytical Method for Estimation of Losartan by using UV – Spectrophotometer
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 4
A simple, accurate, and economical least time consuming method for losartan method has been developed using Uv spectrophotometer.The assay is based on the UV absorbance maxima at about wavelength of 234nm using distilled water as solvent. Six sample of drug were dissolved in distilled water to produce solutions containing different brands of losartan. The absorbance of these six drugs we...
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Authors Dr. Safila NaveedRead Journal Click Here
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Page No. 15 to 17
Epilepsy: The Next Generation Drugs (A Review)
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 4
Seizures are common and are treated in all branches of medicine. Approximately 10% of the population will have one or more seizures during their lifetime. Seizures are symptoms that occur in acute illness, ie, provoked seizures, or in epilepsy, ie, unprovoked seizures. Antiepileptic drugs (AEDs) are pharmacologic agents used to reduce the frequency of epileptic seizures. “...
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Authors Amit K. Shrivastava, Manish Dhar Dwivedi, Gulzar AlamRead Journal Click Here
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Page No. 19 to 27
Comparative Study of Different Brands of Alprazolam
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 3
Benzodizapenes are the most widely used anxiolytic drug. They have largely replaced barbiturates and meprobamate in the treatment of Anxiety because they are safer and more effective. Alprazolam belongs to this class of drugs, it is used for the treatment of the anxiety symptoms of panic disorders.Present study deals with a brief overview of the comparative study of different brands of A...
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Authors Dr. Safila Naveed, Fatima QamarRead Journal Click Here
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Page No. 25 to 28
