B: Pharma, Drug Discovery, Toxicology & Medicine (132)
GJMR: B
Collection, Detection, Assessment, Monitoring and Prevention of Adverse Drug Reactions in the Nephrology Department of Gauhati Medical College and Hospital, Assam, India
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 3
An adverse drug reaction (ADR) as defined by World Health Organization (WHO) is a noxious, unintended effect of a drug, occurring at normal doses in humans for prophylaxis, diagnosis or therapy of disease or for the modification of physiological function. ADRs are considered as the fourth to sixth leading cause of death among hospitalized patients. About 2.9-5.6% of all admissions are ca...
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Authors Prudhivi Ramakrishna, AK Barman, PJMahanta, Mangala Lahkar, Maddi RamaiahRead Journal Click Here
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Page No. 29 to 33
Acute and Sub-Acute (28-Day) Oral Toxicity Studies of Ethanolic Extract of Celtis Timorensis Leaves in Rodents
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 3
Aim of the study: The present study was carried out to evaluate the safety of ethanolic extract of celtis timorensis (EECT) by acute and sub-acute toxicity studies. Materials and Methods: Acute toxicity study was conducted in mice by using OECD 425 guidelines whereas sub-acute toxicity study was carried out in rats by using OECD 407 guidelines. In the acute toxicity study, mice were admi...
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Authors Prasanth Kumar. M, Suba. V, Ramireddy. B, Srinivas Babu.PRead Journal Click Here
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Page No. 7 to 13
Efficacy of Bee Venom as an Anti-Viral Therapy for HCV Genotype 4
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 3
Use of traditional medicine is encouraged in many economically diverse countries when conventional medications fail. HCV prevalence is highest in Egypt at >10% of the general population, and China has the most people with HCV (29.8 million); approximately 52% of patients infected with HCV genotype 4 will develop chronic HCV.The use of interferon, currently the only approved therapy, is f...
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Authors Abd Elrazek M Ali Abd Elrazek, UsamaM. Abdel-Aal.Read Journal Click Here
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Page No. 15 to 18
Simple UV Spectrophotometric Assay of Atorvastatin API Formulation and their Comparative Study
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 2
A rapid, simple, accurate, and economical least time consuming rosuvastatin spectrophotometric method has been developed for the assay of atorvastatin and then compare assay of brand available in Karachi,Pakistan. The assay is based on the ultraviolet UV absorbance maxima at about 244nm wavelength of atorvastatin using methanol as solvent. A sample of drug was dissolved in methanol to pr...
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Authors Dr. Safila NaveedRead Journal Click Here
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Page No. 35 to 38
Phytochemical and Pharmacological Evaluation of Fruits of Sonneratia apetala
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 3
Sonneratia apetala-Buch.- Ham is a mangrove tree from the family, Lythraceae. The aim of the study is to evaluate analgesic, antidirrhoeal, anthelmintic, cytotoxic activity of the fruits of S. apetala. The extract showed dose dependent analgesic activity using acetic acid induced writhing inhibition of the Swiss albino mice. The extract produced 46% and 69% writhing inhibition at the dos...
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Authors Anha Afrin Shefa, Farzana Shabnam Baishakhi, Sharmin Islam, Samir Kumar SadhuRead Journal Click Here
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Page No. 1 to 6
Assessment of Adequate use of Asthma Inhalational Medication Administration in Children in Gondar University Teaching Hospital, Northwest Ethiopia
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 2
Introduction: Asthma and other chronic airway diseases can be effectively treated by inhaler therapy. Inhaler therapy depends on appropriate use of the inhaler. For asthma, inhalation therapy is the foundation of treatment. Yet all too often, patients do not get the full value of their inhaled medications because they use their inhaler incorrectly. The objective of this study was to eval...
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Authors Belayneh Kefale Gelaw, Yitayih Kefale GelawRead Journal Click Here
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Page No. 39 to 45
New Process Based on the Coupling of an Electrochemical Sensor and Bioanalytical Column for Determining Antioxidant Capacity
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 2
A new approach, for antioxidant capacity determination was proposed. It is based on the using of the xanthine-xanthine oxidase system coupled with H2O2 electrochemical sensor. The paper presents the preparation and characterization of the H2O2 amperometric sensor and its utilization for antioxidant evaluation of some real samples (Garlic, tea and coffee). The obtained results were found ...
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Authors Ngono Thu00c3u00a9ru00c3u00a8se Rosie Lauriane, Rachida Najih, Abdelilah ChtainiRead Journal Click Here
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Page No. 47 to 51
Development and Validation of RP-HPLC Method For Simultaneous Determination of Guaifenesin Impurities in MultiDrug Combinations
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 2
A High Performance Liquid Chromatographic method was developed and validated for quantitative determination of Guaifenesin impurities including 2-(2- methoxyphenoxy)propane-1,3-diol (β-isomer) and 2- m ethoxyphenol (guaiacol) in different multi drug components pharmaceutical dosage forms, containing guaifenesin, ambroxol hydrochloride and salbutamol sulfate . The different analyti...
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Authors Levon A. Melikyan, Rosa S. Grigoryan, Tigran K. DavtyanRead Journal Click Here
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Page No. 27 to 34
A Study of Single and Combined Cytotoxic Effects of Fumonisin B1, Aflatoxin B1 and Ochratoxin a on Human Mononuclear Blood Cells using Different Cytotoxic Methods
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 2
Several studies on cereals destined for animal or human consumption in South Africa and Africa have shown co-contaminations of mycotoxins. There is evidence to suggest that the simultaneous action of different mycotoxins at various concentrations might have synergistic, inhibitive or additive effects on human and animal cells.The aims of this study were to identify combined cytotoxic eff...
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Authors Mwanza Mulunda, Michael F DuttonRead Journal Click Here
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Page No. 1 to 19
Renal Parameters as Predictors of Morbidity and Mortality in Snake Bite Patientsin a Tertiary Care Hospital in Southern India
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 2
Background: Snake bite is predominantly an occupational hazard and a common cause of morbidity and mortality. Acute renal failure has been associated with venomous viper and sea snake bites. AIMS: This study was carried out to study the incidence and clinical profile of the snake bite patients who develop acute renal failure;and to identify the predictors of morbidity and mortality in th...
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Authors Imtiaz Pasha, Srinivasa Prabhu N C, Harsha Vardhana H S, Preethika Ravi, AmiraRead Journal Click Here
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Page No. 21 to 26
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Effect of Antioxidant Vitamins on the Oxidant / Antioxidant Status in Patients with Multiple Sclerosis
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 1
Background: The cause of multiple sclerosis (MS) is unknown, although it is widely accepted that environmental factors act in concert with a genetic susceptibility. Objective: To evaluate the effect of 3 months supplementation of antioxidants vitamins (ascorbic acid (vitamin C) and alphatocopherol (vitamin E)) on the oxidant / antioxidant status and on the clinical course in patients wit...
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Authors Meena Ahmed Mohammed, Assist. Prof. Dr. Wahda B. Al-YouzbakiRead Journal Click Here
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Page No. 29 to 34
Urinary Excretion and Renal Clearance of Nimesulide in Male Volunteers
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 1
Drugs are eliminated from the body either unchanged as the parent drug or as metabolites. Nimesulide drug belongs to a wide class of medicines called antiinflammatory nonsteroidal drugs (NSAID). NSAIDs are well known for their antipyretic, anti-inflammatory, and analgesic properties. Renal clearance of nimesulide correlated with creatinine clearance. The present research work was planed ...
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Authors Bilal Ahmed, Tahira Iqbal, Huma Mahboob, Farah Latif, Imtiaz Sohail.Read Journal Click Here
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Page No. 23 to 27
Fascinating Nutritional, Prophylactic, Therapeutic and Socio-Economic Reconcile Attributable to Drum Stick Tree (Moringa Oleifera Lam.)
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 1
Different parts of this M. oleifera ( Drum Stick Tree ) contain a profile of important minerals, and are a good source of vitamins, β-carotene, amino acids and various phenolics. The Moringa plant provides a rich and rare combination of zeatin, quercetin, β-sitosterol, caffeoylquinic acid and kaempferol. In addition to its compelling water purifying powers and high nutritio...
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Authors Raaz K Maheshwari, Rajesh K Yadav, Jayant Malhotra, Nidhi Gauba Dhawan, Lalit Mohan, Rajnee, BL Jat, Bhavna Upadhyay, Bina Rani,Read Journal Click Here
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Page No. 11 to 22
Effect of Caffeine-Containing Beverages on Physicochemical and Release Properties of Halofantrine
Published In: GJMR Part: B: Pharma, Drug Discovery, Toxicology & Medicine Volume: 14 Issue: 1
Halofantrine (Hf) is a poorly water-soluble drug for treating malaria in endemic areas like tropical Africa, where caffeine-containing products are habitually consumed. Previous reports showed that caffeine increased the aqueous solubility of Hf at room temperature over 3 days. The aim of this study was to determine the effect of caffeine and caffeinecontaining beverages on dissolution a...
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Authors Babalola C. P., Kolade Y. T., Adeyemo M. A., Kotila O. A., Ameh S.J., Adelakun T. A., Adewuyi S., Scriba G.K.Read Journal Click Here
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Page No. 5 to 10
